Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PEAQX tetrasodium hydrate (PEAQX tetrasodium hydrate (459836-30-7 free base)) 是一种可口服的NMDA 拮抗剂,具有有效性和选择性。PEAQX tetrasodium hydrate (459836-30-7 free base) 对 hNMDAR 1A/2A 的 IC50 值分别为 270 nM 对hNMDAR 1A/2B 的 IC50 值为29600 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 500 | 现货 | ||
5 mg | ¥ 1,170 | 现货 | ||
10 mg | ¥ 1,730 | 现货 | ||
25 mg | ¥ 2,980 | 现货 | ||
50 mg | ¥ 4,390 | 现货 |
产品描述 | PEAQX tetrasodium hydrate (PEAQX tetrasodium hydrate (459836-30-7 free base)) is an orally available NMDA antagonist that is potent and selective. The IC50 value of PEAQX tetrasodium hydrate (459836-30-7 free base) against hNMDAR 1A/2A was 270 nM and 29600 nM against hNMDAR 1A/2B, respectively. |
靶点活性 | NMDAR 1A/2B (human):29600 nM, NMDAR 1A/2A (human):270 nM |
体外活性 | PEAQX 对 NMDA 受体具有高亲和力(IC50=8 nM),并对 hNMDA 1A/2A(IC50=270 nM)的功能偏好超过 100 倍,远高于 1A/2B 受体(IC50=29,600 nM)。[1] |
体内活性 |
PEAQX is practically inactive in Xenopus oocytes expressing hNMDA 1A/2B receptors, displays an ED50 value of 23 mg/kg in the MES test [1]. Sprague-Dawley rats were treated on PN7, PN9, and PN11 with PCP (10 mg/kg), PEAQX (NR2A-preferring antagonist; 10, 20, or 40 mg/kg), or ifenprodil (selective NR2B antagonist; 1, 5, or 10 mg/kg) and sacrificed for measurement of caspase-3 activity (an index of apoptosis) or allowed to age and tested for locomotor sensitization to PCP challenge on PN28-PN35. PCP or PEAQX on PN7, PN9, and PN11 markedly elevated caspase-3 activity in the cortex; ifenprodil showed no effect. Striatal apoptosis was evident only after subchronic treatment with a high dose of PEAQX (20 mg/kg). Animals treated with PCP or PEAQX on PN7, PN9, and PN11 showed a sensitized locomotor response to the PCP challenge on PN28-PN35.[2] |
别名 | NVP-AAM077 tetrasodium hydrate, PEAQX tetrasodium hydrate (459836-30-7 free base), PEAQX tetrasodium hydrate |
分子量 | 560.15 |
分子式 | C17H15BrN3Na4O6P |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 22.9 mg/mL (41.0 mM), Sonication and heating are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 1.7852 mL | 8.9262 mL | 17.8524 mL | 44.6309 mL |
5 mM | 0.357 mL | 1.7852 mL | 3.5705 mL | 8.9262 mL | |
10 mM | 0.1785 mL | 0.8926 mL | 1.7852 mL | 4.4631 mL | |
20 mM | 0.0893 mL | 0.4463 mL | 0.8926 mL | 2.2315 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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